UFC 322 is shaping up to be one of the biggest MMA events of 2025, and the main event between Jack Della Maddalena and Islam Makhachev has fans and bettors buzzing worldwide. Scheduled for Sunday, November 16, 2025, at Madison Square Garden in New York, this Welterweight Title Fight is more than just a clash of champions — it’s a battle of styles, precision, and pride.
Let’s break down the latest betting odds, expert predictions, and smart betting tips to help you make informed picks ahead of UFC 322.
Main Event Overview
In one corner stands Jack Della Maddalena, the Australian knockout artist who’s quickly risen to fame with a string of electrifying finishes. Known for his crisp boxing and calmness under pressure, he’s become one of the UFC’s most technically polished strikers.
In the other corner, you have Islam Makhachev, the reigning Lightweight Champion, stepping up to the Welterweight Division in pursuit of double-champion status. Makhachev’s world-class grappling, elite fight IQ, and ability to control pace make him one of the most dominant fighters in modern UFC history.
This matchup has everything: a deadly striker versus a grappling genius, youth versus experience, and a potential legacy-defining night for both men.
Current UFC 322 Betting Odds (Estimated)
While official odds can shift as the fight approaches, early sportsbooks have released opening lines in the following range:
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Islam Makhachev: -185 (Favorite)
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Jack Della Maddalena: +155 (Underdog)
These numbers suggest that Makhachev is expected to win around 65% of the time, while Della Maddalena carries roughly 35% implied odds of victory. However, styles make fights — and this one has the potential to upset the math.
Fighter Breakdown
Islam Makhachev – The Tactical Dominator
Makhachev has built his career around control, precision, and pressure. His grappling is second to none, and once he gets his hands on an opponent, very few can escape. His ability to transition from takedowns to submissions or ground-and-pound makes him one of the most complete fighters in the UFC.
But this fight is different. Moving up to 170 pounds, Makhachev will face stronger and naturally bigger opponents. His cardio and strength will be tested, especially if Della Maddalena can defend early takedowns and force prolonged exchanges on the feet.
Makhachev’s key to victory will be to close the distance quickly, use chain wrestling, and keep Della Maddalena off balance with clinch pressure and level changes.
Path to victory: Pressure, takedowns, control time, and ground dominance.
Best bet type: Makhachev by Decision (+150 to +200 range).
Jack Della Maddalena – The Precision Striker
Della Maddalena represents the new wave of Australian MMA — calm, composed, and technically sound. His boxing stands out in a division filled with wild punchers. He throws clean combinations, manages distance well, and rarely wastes energy.
The Australian is a natural finisher with a knack for finding openings. He’s patient in exchanges and reads timing better than most opponents. Against Makhachev, his challenge will be to stuff takedowns, keep the fight standing, and make the Russian pay for every failed entry attempt.
If he can stay upright and land clean shots early, he has the power to end the fight in dramatic fashion.
Path to victory: Maintain range, use movement, and counter with power shots.
Best bet type: Della Maddalena by KO/TKO (+300 to +350 range).
Expert Predictions
Many analysts are calling this fight a classic striker vs grappler showdown — the type of matchup that defines eras.
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Safe Pick: Makhachev to win by Unanimous Decision. His control and wrestling give him a consistent path to victory, especially over five rounds.
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Upset Pick: Della Maddalena by KO/TKO in the second or third round. If he can catch Makhachev during a level change or force striking exchanges in open space, the upset is possible.
Betting experts also recommend watching live lines. If Della Maddalena survives the first two rounds, the odds will likely swing, offering strong mid-fight value.
Prop Bets to Consider
Prop bets can be more profitable than moneyline picks if you know the fighters’ tendencies. Here are some smart angles for UFC 322:
| Bet Type | Prediction | Why It’s Valuable |
|---|---|---|
| Fight to Go the Distance: No | (-150) | Both men have high finish rates and aggressive styles. |
| Makhachev by Decision | (+150 to +200) | Likely scenario if he dominates with wrestling. |
| Della Maddalena by KO/TKO | (+300 to +350) | Excellent value given his knockout power. |
| Round 3 Finish | (+400) | Both fighters often find success in mid-rounds when opponents tire. |
Remember, props vary across sportsbooks — always compare odds before placing a bet.
Where to Bet on UFC 322
Fans looking to bet safely and legally on UFC 322 can use top-rated sportsbooks such as:
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Bet365 – Reliable global option with early lines on UFC events.
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Stake.com – Popular among crypto bettors, offering live markets.
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Boomerang Bet – Featured site this month for UFC betting promos.
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DraftKings and FanDuel – U.S.-regulated options with prop bet variety.
Each site offers unique bonuses, so check regional availability and betting rules in your country before wagering.
Betting Tips for UFC 322
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Watch the Weigh-Ins: See how Makhachev handles the jump to welterweight. A tough cut or lack of size difference could change the odds.
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Consider In-Play Bets: Della Maddalena often starts slow; live betting may provide better odds after Round 1.
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Avoid Heavy Parlays: Main event upsets happen often — focus on straight bets or props for controlled risk.
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Track Movement: Early money may push Makhachev’s line lower, creating better value on Della Maddalena later.
Final Thoughts
UFC 322: Della Maddalena vs Makhachev is more than a title fight — it’s a stylistic masterpiece. Makhachev seeks to cement his legacy as a two-division champion, while Della Maddalena aims to prove that elite striking can overcome dominant wrestling.
From a betting perspective, Makhachev remains the safe favorite, but the Australian’s power and precision make him a dangerous underdog. If you’re looking for value, Della Maddalena by knockout is a tempting play — but if you prefer consistency, Makhachev by decision offers reliable odds.
No matter which side you’re on, UFC 322 promises to be a thrilling night for fight fans and bettors alike.
